CagA Positive Helicobacter Pylori Infection in Coronary Atherosclerosis: Discriminative value of lymphocyte to mean platelet volume ratio.

Aim: Potent combined and long-term antithrombotic therapies that predispose to gastric injury are the mainstay of treatment in acute coronary syndromes (ACS). Severe chronic mucosal inflammation due Helicobacter Pylori (H. pylori) infection was shown be associated with higher peripheral blood lymphocytes lower mean platelet volume (MPV) levels. We aimed investigate discriminative usefulness lymphocyte MPV ratio as a simple premise marker for CagA positive H. before required advanced diagnostic tests patients arterial disease (CAD). Materials Methods: A total 293 patients’ who had undergone elective urgent angiography CAD were included study. Serologic pylori status hematological parameters determined. Two groups compared according serology status. Confounding factors adjusted by propensity score matching multivariate logistic regression analysis. Results: Rates ACS, male gender, diabetes mellitus, family history CAD, current smoking seropositive seronegative (p < 0.05). The ROC curve analysis showed at cut-off point 165 71% sensitivity 60% specificity discriminating (AUC = 0.71, p 0.0001). Lymphocyte independently serology. Conclusion: can helpful H infected requiring confirmatory tests.